NAD + / NADH and skeletal muscle mitochondrial adaptations to exercise 4
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1 2 3 NAD/NADH and skeletal muscle mitochondrial adaptations to exercise 4 Amanda T. White and Simon Schenk*. 5 6 Biomedical Sciences Graduate Program and Department of Orthopaedic Surgery, University of 7 California, San Diego. La Jolla, CA 92093. 8 9 * Corresponding Author: Simon Schenk, Department of Orthopaedic Surgery, University of California, 10 San Diego. 9500 Gilman Drive MC0863, La Jolla, CA 92093. Email: [email protected]. Phone: 1 858 11 822 0857. Fax: 1 858 822 3807. 12 13 Running title: NAD-mediated regulation of mitochondrial biogenesis 14 15 16 17 Articles in PresS. Am J Physiol Endocrinol Metab (March 20, 2012). doi:10.1152/ajpendo.00054.2012
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White AT, Schenk S. NAD /NADH and skeletal muscle mitochondrial adaptations to exercise. Am J Physiol Endocrinol Metab 303: E308–E321, 2012. First published March 27, 2012; doi:10.1152/ajpendo.00054.2012.—The pyridine nucleotides, NAD and NADH, are coenzymes that provide oxidoreductive power for the generation of ATP by mitochondria. In skeletal muscle, exercise perturbs the levels of NAD , NAD...
متن کاملNAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise.
The pyridine nucleotides, NAD(+) and NADH, are coenzymes that provide oxidoreductive power for the generation of ATP by mitochondria. In skeletal muscle, exercise perturbs the levels of NAD(+), NADH, and consequently, the NAD(+)/NADH ratio, and initial research in this area focused on the contribution of redox control to ATP production. More recently, numerous signaling pathways that are sensit...
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Skeletal muscle can maintain ATP concentration constant during the transition from rest to exercise, whereas metabolic reaction rates may increase substantially. Among the key regulatory factors of skeletal muscle energy metabolism during exercise, the dynamics of cytosolic and mitochondrial NADH and NAD+ have not been characterized. To quantify these regulatory factors, we have developed a phy...
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تاریخ انتشار 2012